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本片根据美国畅销作家丹?布朗的同名小说改编。欧洲核子中心的科学家维多利亚?维特勒（阿耶莱特?祖瑞尔 Ayelet Zurer 饰）与父亲在高速粒子对撞机实验中收集到了反物质，却发现父亲遇害，尸体胸口被烙“光照派”符号，高爆炸性的反物质被偷走，出现在正待选新教皇的罗马梵蒂冈，威胁天主教廷及整个罗马的安危。于此同时，四位主要教皇候选人的红衣主教神秘失踪。在教皇内侍（伊万?麦克格雷格 Ewan McGregor 饰）的授意下，哈佛大学的符号学专家罗伯特?兰登教授和维多利亚都被请到梵蒂冈协助罗马警察开展搜寻行动。兰登说服罗马总探员奥利维迪（皮耶法兰西斯柯?法维诺Pierfrancesco Favino 饰）依照“土、气、火、水”的提示在罗马的名胜教堂间与“光照派”展开了时间战……
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